个人资料
赵琳琳
同济大学医学院 生物化学与分子药理学
地址：上海市普陀区真南路500号 200062
联系电话：13916546791
Email：lzhao@tongji.edu.cn
研究方向
利用溶液核磁共振技术，解析肿瘤免疫重要靶点膜受体的三维结构，挖掘细胞膜脂组分对受体蛋白功能的动态调控机制；
利用大分子药物筛选平台，以蛋白质结构为指导，开展精准抗体及T细胞接合器的筛选与设计，对接临床应用。
教育及工作经历
2021年11月-至今：研究员，同济大学医学院，生化与分子生物学系
2017年10月-2021年8月：博士后，美国哈佛大学医学院，生化与分子药理学系
2012年9月-2017年7月：硕博连读，中科院生物化学与细胞生物学研究所，生物化学
2008年9月-2012年7月：本科，山东大学生命科学学院，微生物发酵
科研业绩
赵琳琳研究员致力于探索肿瘤免疫领域重要细胞膜受体的分子机制，利用生物物理学、细胞生物学、生物化学等多学科交叉背景，建立了从受体蛋白动态成像、细胞功能机制鉴定到靶向抗体筛选的完整研究体系，先后在Cell, Cell Research, Nature Structural
& Molecular Biology, EMBO J, Cell Reports, Nature Communications, Communications Biology, Structure, Protein Cell, Frontier Cell Dev Biol,
Biochemistry等重要期刊发表高水平论文。入选上海市海外高层次人才引进、上海市卫生健康青年人才、同济大学百人计划等，上海市第十人民医院双聘研究员。
代表性论文 #第一作者, *通讯作者。
1. Xu, X.#, Wang, Y.#, Wu, Y., Cai, Z., Zhu, J., Wu, H., ... & Zhao, L.* (2026). Membrane engagement by the HLA-A cytoplasmic tail regulates endocytosis and surface retention. Cell Reports, 45(9).
2. Zhu, J.#, Xu, X.#, Liu, P., Wu, H., Wang, Y., Xu, B., ... & Zhao, L.* (2026). A conserved basic motif mediates membrane anchoring and TRAF2 recruitment across costimulatory TNFRs. The EMBO Journal, 1-24.
3. Liu, P.#, Zhao, Y.#, Cai, Z., Wu, H., Wang, S., Jiang, L., ... & Zhao, L.* (2026). A humanized anti-TNFR1 nanobody antagonist targeting the CRD3 region suppresses inflammation and necroptosis in vitro. Communications Biology.
4. Wu, Y., Hu, W., Zhao, L.* (2026). From Prediction
to Design: A Paradigm Shift in AI-Driven Protein–Protein Interaction Research. Health and Metabolism.
5. Zhu, J.#, Chen, Z.#, Xu, X., Wang, Y., Liu, P., Wen, M., ... & Zhao, L.* (2025). Structure guided analysis of KRAS G12 mutants in HLA-A* 11: 01 reveals a length encoded immunogenic advantage in G12D. Communications Biology, 9(1), 26.
6. Ahmad, S.#, Zou, T.#, Hwang, J.#, Zhao, L.#, Wang, X., Davydenko, A., ... & Hur, S.* (2025). PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration. Nature Communications, 16(1), 3325.
7. Du, G.#, Zhao, L.#, Zheng, Y., Belfetmi, A., Cai, T., Xu, B., ... & Chou, J. J.* (2023). Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Research, 33(2), 131-146.
8. Zhao L, Fu Q, Pan L, Piai A, Chou JJ.* (2020). The diversity and similarity of transmembrane trimerization of TNF receptors. Frontier Cell Dev Biol, 8, 1096.
9. Pan, L.#, Fu, T. M.#, Zhao, W.#, Zhao, L.#, Chen, W., Qiu, C., ... & Chen, S.* (2019). Higher-order clustering of the transmembrane anchor of DR5 drives signaling. Cell, 176(6), 1477-1489.
10. Fu, T., Pan, L., Zhao, L., Wu, H., & Chou, J.* (2019). Higher‐Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. The FASEB Journal, 33(S1), 792-3.
11. Yang, Q., Brüschweiler, S., Zhao, L., & Chou, J. J.* (2018). Reply to ‘Concerns with yeast mitochondrial ADP/ATP carrier’s integrity in DPC’and ‘Dynamics and interactions of AAC3 in DPC are not functionally relevant’. Nature structural & molecular biology, 25(9), 749-750.
12. Zhao, L., Wang, S., Zhu, Q., Wu, B., Liu, Z., OuYang, B., & Chou, J. J.* (2017). Specific interaction of the human mitochondrial uncoupling protein 1 with free long-chain fatty acid. Structure, 25(9), 1371-1379.
13. Zhao, L.#, Wang, S.#, Run, C., OuYang, B., & Chou, J. J.* (2016). Specific lipid binding of membrane proteins in detergent micelles characterized by NMR and molecular dynamics. Biochemistry, 55(38), 5317-5320.
14. Zhao, L., Wang, S., Du, L., Dev, J., Zhou, L., Liu, Z., ... & OuYang, B.* (2016). Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein & cell, 7(4), 300-304.