脑疾病相关蛋白聚集与传播课题组

Lab of Proteinopathies in Neurodegenerative Diseases

Papers

Ø Penghao Ji#, Chengjie Li#, Yang Tang, Jiachang Hong, Wei Liu, Dongliang Huo, Shixiong Kang, Rongmin Dun, Fei Zhu, Liying Wang, Shutong Liu, Qihui Wu*, Peng Wu*, Minfeng Huo* and Jianlin ShiMetal-Phenolic Strontium Caffeic Acid Nanocatalysts Potentiate TRPV1 Blockade and Osteomodulation for Arthritic Analgesia and Progression Amelioration. ACS Nano. 2026, Accepted (Key words: TRPV1, DRG, pain) (IF=17.3)


Ø Ming Yin#, Chenlong He#, Yuwei Wang#, Jingwen Qin, Huawei Liu, Han Zhou, Hongyi Zhang, Shan Hua, Shengming Wu, Jing Chen, Keyue Xiao, Qihui Wu*, Yilong Wang*. Biomimetic Hybrid Fibers Integrates Scaffold Topology and Bioinert Protein Cues to Harmonize Microglial Phagocytosis and Anti-Neuroinflammation. Chemical Engineering Journal. 546 (2026) 180663. https://doi.org/10.1016/j.cej.2026.180663 (Key words: Neuroinflammation, phagocytosis, PD) (IF=13.2)


Ø Xinwei Huang*,#, Yihan Liu#, Qingyuan Miao#, Hong Zhang#, Xin Tang, Ban Feng, Lushun Zhang, Tingting Dan, Li Tian, Peilin Cong, Qiuhong Man, Qing Xia, Enduo Feng, Qian Chen, Hui Zhang, Xinyang Li, Qianqian Wu, Qian Zhang, Yinggang Zheng*, Qihui Wu*, Lize Xiong*. Preclinical assessment of intravenous human Ficolin-2 administration for Alzheimer's disease. Genes & Diseases. Available online 2 August 2026, 102391 (Key words: FCN2, AD therapy) (IF=14.6)


Ø Rong Huang # , Xingyu Du # , Qihui Wu # , Yuan Wang , Yuqi Hang , Xi Wu , Yiman Li , Jie Li , Zhongjun Qiao, Yinglin Li, Lili Yin, Xiaoxuan Sun, Bing Liu, Feipeng Zhu, Quanfeng Zhang , Changhe Wang, Zuying Chai , Zhuan Zhou. Ca2+-Independent Exocytosis Favors Axonal Release through Enlarged Fusion Pores in Sensory Neurons. Neuroscience Bulletin. 2026 Feb 26.  doi: 10.1007/s12264-026-01595-5. Online ahead of print. (Key words: TIRF, CIVDS, DRG neuron) (IF=6.8)


Ø Chengjie Li#, Weixian Kong#, Yali Li#, Junxin Wang, Yunjie Zou, Yu Liu, Yihan Liu, Linlin Zhou, Long Guo, Dafei Xu, Pu Ai, Yuwei Wang, Ruiyan Li, Xinyue Zhang, Biqi Zou, Ge Gao, Zhenyu Cai, Fuquan Long*, Yong Bi*, Jialin Zheng*, Jianhui Liu*, Qihui Wu*Serine endopeptidase TPP2 sustains lysosomal homeostasis to alleviate Parkinson's disease pathogenesis. Neural Regeneration Research. 2026 Apr 14.  doi: 10.4103/NRR.NRR-D-25-00817.  Online ahead of print. (Key words: SEP, BONCAT labeling, PD) (IF=8.5)


Ø Linlin Zhou (周林林), Qihui Wu (吴齐辉)*Protocol for co-culture of primary neurons and organotypic hippocampal brain slices from miceSTAR Protocols. Volume 6, Issue 4, 19 December 2025, 104228. https://doi.org/10.1016/j.xpro.2025.104228. (Key words: Brain slice culture, AD, PD) 


Ø Yu Liu#, Weixian Kong#, Feipeng Zhu#, Jinwen Jiang, Cui Li, Jiale Han, Pu Ai, Chengjie Li, Yuwei Wang, Yihan Liu, Linlin Zhou, Ruiyan Li, Xiaoyang Guo, Yitong Ji, Long Guo, Ke Xu, Zhenyu Cai, Yong Bi, Virginia Man-Yee Lee, Jialin Zheng*, Qihui Wu *. Chromogranin A promotes the pathological conversion of α-synuclein at the synapse in Parkinson’s disease. Cell Reports. 2025 Nov 15;44(11):116562. doi: 10.1016/j.celrep.2025.116562. (Key words: CgA, PD) (IF=8.2)

 

Ø Linlin Zhou#, Yuwei Wang#, Yu Liu#, Feipeng Zhu#, Ge Gao#, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Virginia Man-Yee Lee, Jianjun Chen*, Jialin Zheng*, Qihui Wu*. Dynein-dependent endo-lysosomal degradation drives Lewy body disorders accompanied by Aβ pathologyAdvanced Science. 2025 Jul 18:e14860. doi: 10.1002/advs.202414860.  (Key words: Dynein, endo-lysosome, PD) (IF=14.1)

 

Ø Yihan Liu, Shengyang Fu, Yan He, Xinwei Huang, Huikang Xie, Leyan Chen, Qihui Wu *, Jialin C. Zheng *, Weijun Cao *, Antioxidative ceria nanoparticles protect acute lung injury-induced cognitive and emotional dysfunctions in mice. Chemical Engineering Journal. Available online 25 May 2025, 164147. https://doi.org/10.1016/j.cej.2025.164147 (Key words: Antioxidative nanoparticle, lung-brain axis) (IF=13.2)

 

Ø Xiaoliang Fang†, Yi Zhong†, Rui Zheng†, Qihui Wu†, Yu Liu, Dexin Zhang, Yuwei Wang, Wubing Ding, Kaiyuan Wang, Fengbo Zhong, Kai Lin, Xiaohui Yao, Qingxun Hu, Xiaofei Li, Guofeng Xu , Na Liu , Jing Nie , Dali Li , Hongquan Geng *, Yuting Guan *PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases, 2025, Science Advances. https://www.science.org/doi/pdf/10.1126/sciadv.adr8648 (Key words: PPDPF, NAD, CKD) (IF=12.5)


Ø Weixian Kong#, Yu Liu#, Pu Ai#, Yong Bi#, Chaoguang Wei, Xiaoyang Guo, Zhenyu Cai, Ge Gao, Peng Hu, Jialin Zheng, Jianhui Liu#, Minfeng Huo#, Yuting Guan# & Qihui Wu#. Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s diseaseJ Nanobiotechnol 22, 690 (2024). https://doi.org/10.1186/s12951-024-02955-x (Key words: Melanin, astrocyte, PD) (IF=12.6)

 
Ø  Ke Su#, Yu Ma#, Mingshan Zhou#, Yihan Liu, Chengjie Li, Yonghui Jiang, Qihui Wu#, Gang Peng#, Yi Wang#, Shaohua Fan#. De novo missense variants of UNC13A are implicated in epileptic encephalopathies and neurodevelopmental disorders. Genes & Diseases. Available online 6 May 2024, 101315.  https://doi.org/10.1016/j.gendis.2024.101315 (Key words: UNC13A, Ca2+ imaging, epilepsy) (IF=14.6)

Ø  Wu Q, Shaik M, Meymand E, Zhang B, Luk K, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha‐synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathol. 2020 Oct 6. doi: 10.1007/s00401-020-02227-6. (Key words: Neuronal activity, brain slice culture, PD) (IF=17.1)

 
Ø  Wu Q, Takano H, Riddle DM, Trojanowski JQ, Coulter DA, Lee VM. α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons. J Neurosci. 2019 Jun 26;39(26):5080-5094. (Key words: Syn PFFs, electrophysiology, PD)
 
Ø  Zhang Q*, Liu B*, Wu Q*, Liu B, Li Y, Sun S, Wang Y, Wu X, Chai Z, Jiang X, Liu X, Hu M, Wang Y, Yang Y, Wang L, Kang X, Xiong Y, Zhou Y, Chen X, Zheng L, Zhang B, Wang C, Zhu F, Zhou Z. Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells. Neuron. 2019 Apr 3;102(1):173-183.e4. (Key words: neurotransmitter co-release, TIRF)
 
Ø  Wu Q*, Zhang Q*, Liu B, Li Y, Wu X, Kuo S, Zheng L, Wang C, Zhu F, Zhou Z. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode in Mammalian Adrenal Chromaffin CellsJ Neurosci. 2019 Jan 9;39(2):199-211. (Key words: Dyn1, TIRF, fusion pore)
 
Ø  Wang Y*, Wu Q*, Hu M, Liu B, Chai Z, Huang R, Wang Y, Xu H, Zhou L, Zheng L, Wang C, Zhou Z. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neuronsSci Signal. 2017 Jun 20;10(484). (Key words: TRPV1 vs VGCC, DRG, TIRF) (Cover story).
 
Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p). 

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