脑疾病相关蛋白聚集与传播课题组

Lab of Proteinopathies in Neurodegenerative Diseases

研究论文

(一)一作/共一作/通讯文章:

Ø  Jiang J, Liu Y, Wu Q#. Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies. Front Neurosci. 2021 Nov 18;15:781722. doi: 10.3389/fnins.2021.781722.eCollection 2021. (# Corresponding author)

 

Ø  Wu Q, Shaik M, Meymand E, Zhang B, Luk K, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha‐synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathol. 2020 Oct 6. doi: 10.1007/s00401-020-02227-6. Online ahead of print. 

 

Ø  Wu Q, Takano H, Riddle DM, Trojanowski JQ, Coulter DA, Lee VM. α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons. J Neurosci. 2019 Jun 26;39(26):5080-5094.

 

Ø  Zhang Q*, Liu B*, Wu Q*, Liu B, Li Y, Sun S, Wang Y, Wu X, Chai Z, Jiang X, Liu X, Hu M, Wang Y, Yang Y, Wang L, Kang X, Xiong Y, Zhou Y, Chen X, Zheng L, Zhang B, Wang C, Zhu F, Zhou Z. Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells. Neuron. 2019 Apr 3;102(1):173-183.e4. (* Co-first author)

 

Ø  Wu Q*, Zhang Q*, Liu B, Li Y, Wu X, Kuo S, Zheng L, Wang C, Zhu F, Zhou Z. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode in Mammalian Adrenal Chromaffin Cells. J Neurosci. 2019 Jan 9;39(2):199-211. 

 

Ø  Wang Y*, Wu Q*, Hu M, Liu B, Chai Z, Huang R, Wang Y, Xu H, Zhou L, Zheng L, Wang C, Zhou Z. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Sci Signal. 2017 Jun 20;10(484). (* Co-first author, Front Cover).

 

Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p). 

 

Ø  Kuo S*, Wu Q*, Liu B*, Xie Z, Wu X, Shang S, Zhang X, Zhou Z. Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese university. J Mol Neurosci. 2014 Jul;53(3):487-92. (* Co-first author)

 

(二)其他参与文章:

Ø  Ji P, An B, Jie Z, Wang L, Qiu S, Ge C, Wu Q, Shi J, Huo M. Genetically engineered probiotics as catalytic glucose depriver for tumor starvation therapy. Mater Today Bio. 2022 Dec 15;18:100515.  doi: 10.1016/j.mtbio.2022.100515. eCollection 2023 Feb.

 

Ø  Zhou H, Jiao B, Ouyang Z, Wu Q, Shen L, Fang L. Report of two pedigrees with heterozygous HTRA1 variants-related cerebral small vessel disease and literature review. Mol Genet Genomic Med. 2022 Oct;10(10):e2032.  doi: 10.1002/mgg3.2032. Epub 2022 Aug 10.

 

Ø  Bassil F, Meymand E, Brown H, Xu H, Cox T, Pattabhiraman S, Maghames C, Wu Q, Zhang B, Trojanowski J, Lee M. α-Synuclein modulates tau spreading in mouse brains. J Exp Med. 2021 Jan 4;218(1):e20192193. doi: 10.1084/jem.20192193.  

 

Ø  Gibbons G, Kim SJ, Wu Q, Riddle DM, Leight SN, Changolkar L, Xu H, Meymand ES, O'Reilly M, Zhang B, Brunden KR, Trojanowski JQ, Lee VM.  Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 2020 Nov 4;15(1):64. doi: 10.1186/s13024-020-00404-5.

 

Ø  Zhang Q, Liu B, Li Y, Yin L, Younus M, Jiang X, Lin Z, Sun S, Huang R, Liu B, Wu Q, Zhu F, Zhou Z. Regulating quantal size of neurotransmitter release through a GPCR voltage sensor. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26985-26995. doi: 10.1073/pnas.2005274117. Epub 2020 Oct 12. 

 

Ø  Wang C, Kang X, Zhou L, Chai Z, Wu Q, Huang R, Xu H, Hu M, Sun X, Sun S, Li J, Jiao R, Zuo P, Zheng L, Yue Z, Zhou Z. Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology. Nat Commun. 2018 Jan 8;9(1):81.

 

Ø  Chai Z, Wang C, Huang R, Wang Y, Zhang X, Wu Q, Wang Y, Wu X, Zheng L, Zhang C, Guo W, Xiong W, Ding J, Zhu F, Zhou Z. CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons. Neuron. 2017 Dec 20;96(6):1317-1326.e4. 

 

Ø  Zhu F, Wu Q, Li J, Grycel K, Liu B, Sun X, Zhou L, Jiao R, Song R, Khan YM, Wang Q, Wang L, Xu Y, Li J, Zhang B, Zhou Z. A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. Cell Calcium. 2017 Nov;67:11-20. 

 

Ø  Fan H, Du X, Zhang J, Zheng H, Lu X, Wu Q, Li H, Wang H, Shi Y, Gao G, Zhou Z, Tan DX, Li X.  Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium. Sci Rep. 2017 Jan 24;7:41226. 

 

Ø  Shang S, Zhu F, Liu B, Chai Z, Wu Q, Hu M, Wang Y, Huang R, Zhang X, Wu X, Sun L, Wang Y, Wang L, Xu H, Teng S, Liu B, Zheng L, Zhang C, Zhang F, Feng X, Zhu D, Wang C, Liu T, Zhu MX, Zhou Z. Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons. J Cell Biol. 2016 Nov 7;215(3):369-381. 

 

Ø  Wang C, Wang Y, Hu M, Chai Z, Wu Q, Huang R, Han W, Zhang CX, Zhou Z. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep. 2016 Jan;17(1):47-63.

 

Ø  Xu H, Zuo P, Wang S, Zhou L, Sun X, Hu M, Liu B, Wu Q, Dou H, Liu B, Zhu F, Teng S, Zhang X, Wang L, Li Q, Jin M, Kang X, Xiong W, Wang C, Zhou Z. Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst. 2015 Jun 7;140(11):3840-5. 

 

Ø  Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, Kang X, Zheng L, Zhang J, Raoux M, Lang J, Li Q, Su J, Yu X, Chen L, Zhou Z. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 2015 Feb;58(2):324-33. 

 

Ø  Kang X, Xu H, Teng S, Zhang X, Deng Z, Zhou L, Zuo P, Liu B, Liu B, Wu Q, Wang L, Hu M, Dou H, Liu W, Zhu F, Li Q, Guo S, Gu J, Lei Q, Lü J, Mu Y, Jin M, Wang S, Jiang W, Liu K, Wang C, Li W, Zhang K, Zhou Z. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15804-9. 

 

Ø  Shang S, Wang C, Liu B, Wu Q, Zhang Q, Liu W, Zheng L, Xu H, Kang X, Zhang X, Wang Y, Zheng H, Wang S, Xiong W, Liu T, Zhou Z. Extracellular Ca²⁺ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. Cell Calcium. 2014 Sep;56(3):202-7. 

 

Ø  Wang L, Zhang X, Xu H, Zhou L, Jiao R, Liu W, Zhu F, Kang X, Liu B, Teng S, Wu Q, Li M, Dou H, Zuo P, Wang C, Wang S, Zhou Z. Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. J Physiol. 2014 Aug 15;592(16):3559-76. 

 

Ø  Wang L, Shang S, Kang X, Teng S, Zhu F, Liu B, Wu Q, Li M, Liu W, Xu H, Zhou L, Jiao R, Dou H, Zuo P, Zhang X, Zheng L, Wang S, Wang C, Zhou Z. Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine. Nat Commun. 2014 May 21;5:3925. 

 

Ø  Zheng L, Wang C, Shang S, Zhang X, Wang Y, Wu Q, Hu M, Chai Z, Wu X, Zheng H, Zhang C, Wang L, Xiong W, Zhou Z. Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells. Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C751-60. 


Ø  Zhang B, Zhang X, Luo P, Huang W, Zhu F, Liu T, Du Y, Wu Q, Lü J, Xiu Y, Liu L, Huang H, Guo S, Zheng H, Zhang C, Zhou Z. Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices. J Physiol. 2012 Feb 15;590(4):753-62. 

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