干细胞生理及疾病治疗研究组

Laboratory of Stem Cell Physiology and Disease Therapy

22. Wang G, Zhang W, Ren J, Zeng Y, Dang X, Tian X, Yu W, Li Z, Ma Y, Yang P, Lu J, Zheng J, Lu B, Xu J, Liang A. The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia. Oncogene. 2024 Jun;43(25):1900-1916. doi: 10.1038/s41388-024-02998-2. Epub 2024 Apr 26. PMID: 38671157; PMCID: PMC11178498.


21. Wang G, Ren J, Zeng X, Chen X, Liang A, Wang X, Xu J. Serine and Arginine-Rich Splicing Factor 3 Promotes the Activation of Quiescent Mouse Neural Stem Cells. Stem Cells Dev. 2024 Feb;33(3-4):79-88. doi: 10.1089/scd.2023.0172. Epub 2024 Jan 18. PMID: 38115601.


20. Zhao S, Xiu G, Wang J, Wen Y, Lu J, Wu B, Wang G, Yang D, Ling B, Du D, Xu J. Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis. J Nanobiotechnology. 2023 Sep 22;21(1):341. doi: 10.1186/s12951-023-02086-9. PMID: 37736726; PMCID: PMC10515007.


19. Zhao, S., Liu, Y., Wang, J., Wen, Y., Wu, B., Yang, D., Wang, G., Xiu, G., Ling, B., Du, D., & Xu, J. (2023). ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A. International immunopharmacology, 120, 110390. https://doi.org/10.1016/j.intimp.2023.110390


18. Jiang T, Xu C, Gao S, Zhang J, Zheng J, Wu X, Lu Q, Cao L, Yang D, Xu J, Chen X. Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor. NPJ Parkinsons Dis. 2022 Oct 6;8(1):127. doi: 10.1038/s41531-022-00394-9.


17. Wu B, Feng J, Guo J, Wang J, Xiu G, Xu J, Ning K, Ling B, Fu Q, Xu J. ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. Stem Cell Res Ther. 2022 Oct 4;13(1):494. doi: 10.1186/s13287-022-03049-x.


16 .Jian Wang # , Rui Hao # , Tianfang Jiang # , Xuanxuan GuoFei Zhou , Limei Cao , Fengjuan Gao , Guangming Wang , Juan Wang , Ke Ning , Chunlong Zhong* , Xu Chen* , Ying Huang* , Jun Xu* , Shane Gao*. Rebuilding Hippocampus Neural Circuit with hADSC-derived Neuron Cells for Treating Ischemic Stroke Cell & Bio  2022 Apr 4;12(1):40  (*Corresponding author)

15. Chuanming Dong#, Xianli Wang#, Lixin Sun#, Liang Zhu, Danjing Yang, Shane Gao, Wenjun Zhang, Bin Ling, Aibin Liang*, Zhengliang Gao*, Jun Xu*. ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway. Stem Cell Res  2022 Jan;58:102618 (Corresponding author)


14Ren J#, Wang X#, Dong C#, Wang G#, Zhang W, Cai C, Qian M, Yang D, Ling B, Ning K, Mao Z, Liu B, Wang T, Xiong L, Wang W*, Liang A*, Gao Z*, Xu J*. Sirt1 Protects Subventricular Zone-Derived Neural Stem Cells from DNA Double-Strand Breaks and Contributes to Olfactory Function Maintenance in Aging Mice. Stem Cells. 2022 May 27;40(5):493-507.   (*Corresponding author)


13.Fangce Wang#,Zheng Li#,Jie Zhou, Guangming Wang,Wenjun zhang*,Jun Xu *Aibin Liang* .SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression. J. Exp. Clin. Cancer Res 2021 Aug 18;40(1):259 (*Corresponding author)


12.Zheng Li#,Fangce Wang#, Xiaoxue Tian, Jun Long, Bin Ling, Wenjun zhang*,Jun Xu *Aibin Liang*. HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML. J. Exp. Clin. Cancer Res 2021 Jun 24;40(1):210 (*Corresponding author)


11.Min-Min Lou#, Xiao-Qiang Tang#,Guang-Ming Wang#, Jia He,Fang Luo,Ming-Feng Guan,Fei Wang,Huan Zou,Jun-Ying Wang,Qun Zhang,Ming-Jian Xu,Qi-Li Shi,Li-Bing Shen,Guo-Ming Ma,Yi Wu,Yao-Yang Zhang,Ai-bin Liang,Ting-Hua Wang,Liu-Lin Xiong,Jian Wang*,Jun Xu* ,Wen-Yuan Wang* Long noncoding RNA BS-DRL1 modulates DNA damage response and genome stability in the central nervous systemby interacting with HMGB1.Nat Commun 2021 Jul 1;12(1):4075 (*Corresponding author)


10. Chen C, Hao X, Lai X, Liu L, Zhu J, Shao H, Huang D, Gu H, Zhang T, Yu Z, Xie L, Zhang X, Yang Y, Xu J, Zhao Y, Lu Z, Zheng J. Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia. Sci Adv. 2021 Mar 10;7(11):eabd6280. doi: 10.1126/sciadv.abd6280. PMID: 33692103; PMCID: PMC7946372.


9. Qiande Hu*, Liang Zhu, Yuan Lia, Jianjun Zhou* , Jun Xu* . bACTA1 is inhibited by PAX3-FOXO1 through RhoA-MKL1-SRF signaling pathway and impairs cell proliferation, migration and tumor growth in Alveolar Rhabdomyosarcoma Cell & Bio 2021 Jan 28;11(1):25  (*Corresponding author)


8. Jian Wang, Xuanxuan Guo, Zhanrong Kang, Lingbin Qi, Ying Yang, Juan Wang, Jun Xu, and Shane Gao. Roles of Exosomes from Mesenchymal Stem Cells in Treating Osteoarthritis. Cell Reprogram  2020 Jun;22(3):107-117


7. Zhuoyi FanHuacheng LuoJie Zhou , Fangce Wang , Wenjun ZhangJian Wang , Shuo Li , Qian Lai , Yueshuang Xu , Guangming Wang , Aibin Liang*Jun Xu*. Checkpoint kinase‑1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair Oncol Rep . 2020 Nov;44(5):2152-2164  (*Corresponding author)


6. Lian Wang , Shengkai Jin , Peibin Dai , Tianran ZhangYanghua Shi , Guihai Ai , Xiaowen Shao , Yutong Xie , Jun Xu*Zhongping Chen*Zhengliang Gao* . p57 Kip2 is a master regulator of human adipose derived stem cell quiescence and senescence . Stem Cell Res 2020 Apr; 44:101759  (*Corresponding author)


5. Ma R, Wang M, Gao S, Zhu L, Yu L, Hu D, Zhu L, Huang W, Zhang W, Deng J, Pan J, He H, Gao Z, Xu J*, Han X*. miR-29a Promotes the Neurite Outgrowth of Rat Neural Stem Cells by Targeting Extracellular Matrix to Repair Brain Injury. Stem Cells Dev 2020 May 1;29(9):599-614  (*Corresponding author)


4. Zhou X, Ning K, Ling B, Chen X, Cheng H, Lu B, Gao Z, Xu J*. Multiple Injections of Autologous Adipose-Derived Stem Cells Accelerate the Burn Wound Healing Process and Promote Blood Vessel Regeneration in a Rat Model. Stem Cells Dev. 2019 28(21):1463-1472  (*Corresponding author)


3. Gao SE, Guo XX, Zhao SM, Jin YP, Zhou F, Yuan P, Cao LM, Wang J, Qiu Y, Sun CX, Kang ZR, Gao FJ, Wei W,  Hu X, Yang DJ, Qin Y, Ning K, Shaw PJ, Zhong GS*, Cheng LM*, Zhu HW*, Gao ZL*, Chen X*, Xu J*, Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury, Cell Death Dis, 2019 Aug 8;10(8):597(*Corresponding author)


2. Sun C, Zhu L, Ma R, Ren J, Wang J, Gao S, Yang D, Ning K, Ling B*, Lu B*, Chen X*, Xu J*. Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes. Cell Death Dis. 2019 Feb 13;10(2):141.


1. Zhu L, Sun C, Ren J, Wang G, Ma R, Sun L, Yang D, Gao S, Ning K, Wang Z, Chen X, Chen S*, Zhu H*, Gao Z*, Xu J*. Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson's disease. Cell Death Dis. 2019 Feb 4;10(2):105. (*Corresponding author)

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