同济大学医学院特聘研究员，同济大学附属第十人民医院双聘研究员，硕士和博士生导师，入选上海市海外高层次人才引进计划、上海市卫生健康委员会青年人才计划。现主持国家自然科学基金委、上海市卫健委、上海市科委等基金项目。博士毕业于浙江大学医学院，随后于浙江大学医学院、美国加州大学伯克利分校分子细胞生物学系从事博士后研究工作。致力于Hippo、Wnt等细胞信号通路的分子调控机制及其在癌症中的功能研究，近来关注于相分离在基因转录调控和肿瘤发生中的作用。以第一/共同第一作者在Nature Cell Biology（2024, 2020）、Cell Research（2017, 2016）、Molecular Biology of the Cell（2022）等杂志发表多篇研究论文。担任Molecular Oncology、Frontiers in Immunology等杂志审稿人，以及国家自然科学基金青年科学基金函评专家。

1. Yi Lu*, Tiantian Wu*, Orit Gutman, Huasong Lu, Qiang Zhou, Yoav I. Henis, Kunxin Luo. Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression. Nature Cell Biology 2020; 22:453-464. (Highlighted in News & Views by Nature Cell Biology; Recommended by F1000)

2. Yi Lu*, Shanshan Xie*, Wen Zhang*, Cheng Zhang, Cheng Gao, Yuqi Cai, Qiang Sun, Zhangqi Xu, Min Xiao, Yanjun Xu, Xiao Huang, Wei Liu, Fudi Wang, Yibin Kang, Tianhua Zhou. Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Research 2017; 27:1422-1440. (Cover Article)

3. Yi Lu, Qingwei Zhu, Douglas M. Fox, Carol Gao, Sarah A. Stanley, Kunxin Luo. SARS-CoV-2 downregulates ACE2 through lysosomal degradation. Molecular Biology of the Cell 2022; 33:ar147.

4. Yi Lu, Chunmei Chang. Phase separation in regulation of autophagy. Frontiers in Cell and Developmental Biology 2022; 10:910640.

5. Yangqing Shao*, Xin Shu*, Yi Lu*, Wenxuan Zhu, Ran Li, Huanyi Fu, Chengyu Li, Wei Sun, Zhuo Li, Yitong Zhang, Xiaolei Cao, Xifu Ye, Emmanuel Ajiboye, Bin Zhao, Long Zhang, Haifan Wu, Xin-Hua Feng, Bing Yang, Huasong Lu. A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation. Nature Cell Biology 2024; 26:86-99.

6. Cheng Zhang*, Wen Zhang*, Yi Lu*, Xiaoyi Yan, Xiumin Yan, Xueliang Zhu, Wei Liu, Yuehong Yang, Tianhua Zhou. NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Cell Research 2016; 26:239-253.

7. Chao Wang*, Ren-jie Tang*, Senhao Kou, Xiaoshu Xu, Yi Lu, Kenda Rauscher, Angela Voelker, Sheng Luan. Mechanisms of calcium homeostasis orchestrate plant growth and immunity. Nature 2024; 627:382-388.

8. Chao Tian*, Shengpeng Wan*, Yi Lu, Ping Wang, Xin Ge, Lan Fang. Reversible manipulation of liquid-liquid phase separation using a chemical-based chemiDroplet. Science Bulletin 2024; 69:441-444.

9. Sijie Feng, Yinlong Song, Minhong Shen, Shanshan Xie, Wenjing Li, Yi Lu, Yuehong Yang, Guangshuo Ou, Jun Zhou, Fudi Wang, Wei Liu, Xiaoyi Yan, Xin Liang, Tianhua Zhou. Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration. Cell Discovery 2017; 3:17032.

*Co-first author