国家“万人计划”科技创新领军人才
科技部中青年科技创新领军人才
地址：上海市普陀区真南路500号
Email：chengguofeng@tongji.edu.cn
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RESEARCH ACHIEVEMENT
程国锋博士长期从事病原性寄生虫和药学等方面研究，在PLoS Pathogens, Adv Sci , Advanced Drug Delivery Reviews, Journal of Biological Chemistry等国内外期刊发表论文100 余篇，参编英文专著3部。相关研究获得上海明治生命科学奖、上海市自然科学二等奖、上海市科技进步奖二等奖（第三完成人），入选科技部中青年科技创新领军人才（2016 年）、国家“万人计划”科技创新领军人才、上海浦江人才、上海市人才发展基金和中国农业科院杰出青年等称号或资助。任或曾任F1000 associate faculty、全国动物卫生标准化技术委员会委员、国家农业科技创新团队首席科学家、农业农村部动物寄生虫学重点实验室副主任等。
HONORS AND AWARDS
获上海市统一战线（工作）先进个人
获国家“万人计划”科技创新领军人才
获中国农业科学院农科英才特殊支持计划
获科技部中青年科技创新领军人才
获中国农业科学院杰出青年称号
获上海市浦江人才称号并获资助
获上海市人才发展资金资助
获上海闵行领军人才
获全国百篇优秀博士论文提名
获上海明治生命科学奖（科学奖）
RESEARCH SUPPORT
1. National Natural Science Foundation of China，Grant No. 31672550, Studies on the mechanism of sexual maturation and egg production regulated by miRNAs in Schistosoma japonicum, 2017/01-2020/12, ￥630,000.00，Principal investigator；
2. Foundation of the Science & Technology Innovation Program of China, Animal schistosomiasis and prevention and control technology, 2014/01-2023/12，Over ￥10,000,000.00，Principal investigator；
3. Talents in Leading Scientific and Technological Innovation of the National "Ten thousand talents Plan"，2017，Veterinary parasitology，￥800,000.00，Principal investigator；
4. National Key Research and Development Plan of Sub-project, Grant No. 2017YFD0501306，Identification of diagnostic biomarkers for schistosomiasis，2017/07-2020/12，￥400,000.00，Principal investigator；
5. Leading Project from Chinese Academy of Agricultural Sciences，Studies on mechanism of sexual maturation and egg production regulated by miRNAs in Schistosoma japonicum，2016/09-2017/12，￥350,000.00, Principal investigator；
6. National Natural Science Foundation of China，Grant No. 31472187, Studies on mechanism of key signal molecules involved in sexual maturation and egg production, 2015/01-2018/12, ￥830,000.00, Principal investigator；
7. National Natural Science Foundation of China，Grant No. 30901068，Identification and characterization of miRNAs involved in sexual maturation and egg production in Schistosoma japonicum，2010/01-2012/12，￥200,000.00，Principal investigator；
8. Shanghai Pujiang Talent Plan, Grant No. 10PJ1412300，Characterization of miRNAs from Schistosoma japoncium，2010/07-2012/06，￥200,000.00，Principal investigator；
9. Shanghai Science and Technology Commission International Cooperation Project，Grant No. 1041070340，Functional characterization of SjIAP，2010/04-2012/03，￥200,000.00，Principal investigator；
10. Basic Foundation for Scientific Research of State-level Public Welfare Institutes of China，Grant No. 2008JB08，Key molecules involved in schistosome development and parasitism，2008/08-2009/12，￥500,000.00，Principal investigator。
PRESENTATIONS FOR INTERNATIONAL CONFERENCES
1. 2018, 8/19-24, Schistosoma japonicum IAP and Teg20 safeguard tegumental integrity by inhibiting cellular apoptosis. 14th International Congress of Parasitology-NTD Asia 2018, Daegu, Korea (Invited speaker)；
2. 2017, 9/3-8, Schistosoma japonicum exosome-delivered miRNAs modulate immune responses in host macrophages.10th Hydra Conference on Molecular and Cellular Biology of Helminth Parasites, Hydra, Greece (Invited speaker)；
3. 2016, 2/15-18, Proteomic and phosphoproteomic analyses of differentially expressed proteins between male and female worms in Schistosoma japonicum. 7th International Conference on Drug Discovery and Therapy, Sharjah, UAE (Invited speaker and session chairman)；
4. 2015, 8/31-9/5, Schistosomes and miRNAs. 9th Hydra Conference on Molecular and Cellular Biology of Helminth Parasites, Hydra, Greece；
5. 2014, 6/26-29, Phosphoproteomic analysis of schistosomes: characterization of phosphorylated proteins in the different stages and sex of Schistosoma japonicum. 4th Annual World Congress of Microbes-2014, Dalian, China (Invited speaker)。
PUBLICATION(*Corresponding author)
1. Giri BR, Li S, Cheng G*. Exogenous modification of EL-4 T cell extracellular vesicles with miR-155 induce macrophage into M1-type polarization. Drug Deliv Transl Res. 2023 Oct 10. doi: 10.1007/s13346-023-01442-4.
2. Liu J, Wang X, Sheng F, Giri BR, Li S, Xia T, Li X, Cheng G*. Metagenomic sequencing for identifying pathogen-specific circulating DNAs and development of diagnostic methods for schistosomiasis. iScience. 2023 Jul 27;26(9):107495. doi: 10.1016/j.isci.2023.107495.
3. Pakharukova MY, Savina E, Ponomarev DV, Gubanova NV, Zaparina O, Zakirova EG, Cheng G, Tikhonova OV, Mordvinov VA. Proteomic characterization of Opisthorchis felineus exosome-like vesicles and their uptake by human cholangiocytes. J Proteomics. 2023 Jul 15;283-284:104927.
4. Zhang M, Huang Y, Zou J, Yang Y, Yao Y, Cheng G*, Yang Y*. Advanced Oxidation Nanoprocessing Boosts Immunogenicity of Whole Tumor Cells. Adv Sci (Weinh). 2023 May 21:e2302250.
5. Giri BR, Cheng G*. Editorial: Roles of non-coding RNAs in infectious diseases - volume II. Front Cell Infect Microbiol. 2023 Apr 25;13:1202616.
6. Giri BR, Li S, Fang C, Qiu L, Yan S, Pakharukova MY, Cheng G*. Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection. Front Immunol. 2022 Sep 2;13:911139.
7. Giri BR, Fang C, Cheng G*. Genome-wide identification of circular RNAs in adult Schistosoma japonicum. Int J Parasitol. 2022 Aug;52(9):629-636.
8. Li S, Giri BR, Liu J, He X, Cai P, Jing Z, Cheng G*. Characterization of MicroRNA Cargo of Extracellular Vesicles Isolated From the Plasma of Schistosoma japonicum-Infected Mice. Front Cell Infect Microbiol. 2022 Feb 28;12:803242.
9. Zaparina OG, Rakhmetova AS, Kolosova NG, Cheng G, Mordvinov VA, Pakharukova MY. Antioxidants resveratrol and SkQ1 attenuate praziquantel adverse effects on the liver in Opisthorchis felineus infected hamsters. Acta Trop. 2021 May 9:105954.
10. Qadeer A, Giri BR, Ullah H, Cheng G*. Transcriptional profiles of genes potentially involved in extracellular vesicle biogenesis in Schistosoma japonicum. Acta Trop. 2021 May;217:105851.
11. Xia T, Giri BR, Liu J, Du P, Li X, Li X, Li S, Cheng G*. RNA sequencing analysis of altered expression of long noncoding RNAs associated with Schistosoma japonicum infection in the murine liver and spleen. Parasit Vectors. 2020 Dec 1;13(1):601.
12. Du P, Giri BR, Liu J, Xia T, Grevelding CG, Cheng G*. Proteomic and deep sequencing analysis of extracellular vesicles isolated from adult male and female Schistosoma japonicum. PLoS Negl Trop Dis. 2020 Sep 28;14(9):e0008618.
13. Liu J, Li H, Xia T, Du P, Giri B, Li X, Li X, Cheng G*. Identification of Schistosoma japonicum GSK3beta interacting partners by yeast two-hybrid screening and its role in parasite survival. Parasitol Res. 2020 Jul;119(7):2217-2226.
14. Chen Y, Giri BR, Li X, He X, Jing Z, Cheng G*. Preliminary evaluation of the diagnostic potential of Schistosoma japonicum extracellular vesicle proteins for Schistosomiasis japonica. Acta Trop. 2020 Jan;201:105184.
15. Giri BR, Cheng G*. Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection. Int J Parasitol. 2019 Dec;49(13-14):993-997.
16. Liu J, Zhu L, Wang J, Qiu L, Chen Y, Davis RE, Cheng G*. Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism. PLoS Pathog. 2019 June. doi.org/10.1371/journal.ppat.1007817. (2018 SCI IF=6.463)
17. Giri BR, Cheng G*. MicroRNAs, T cell immunity and immunotherapy. Future Medicinal Chemistry. 2019 (in press). (2018 SCI IF=3.671)
18. Giri BR, Mahato RI, Cheng G*. Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases. Med Res Rev. 2019 Mar;39(2):706-732. (2018 SCI IF=9.791)
19. Liu J, Giri BR, Chen Y, Cheng G*. 14-3-3 protein and ubiquitin C acting as SjIAP interaction partners facilitate tegumental integrity in Schistosoma japonicum. Int J Parasitol. 2019 Apr;49(5):355-364. (201SCI IF=3.478)
20. Liu J, Giri BR, Chen Y, Luo R, Xia T, Grevelding CG, Cheng G*. Schistosoma japonicum IAP and Teg20 safeguard tegumental integrity by inhibiting cellular apoptosis. PLoS Negl Trop Dis. 2018 Jul 25;12(7):e0006654. (2018SCI IF=4.487)
21. Wang L, Giri BR, Chen Y, Xia T, Liu J, Li H, Li J, Cheng G*. Molecular characterization, expression profile, and preliminary evaluation of diagnostic potential of CD63 in Schistosoma japonicum. Parasitol Res. 2018 Nov;117(11):3625-3631. (2018 SCI IF=2.558)
22. Giri BR, Li H, Chen Y, Cheng G*. Preliminary evaluation of neoblast-like stem cell factor and transcript expression profiles in Schistosoma japonicum. Acta Trop. 2018 Nov;187:57-64. (2018 SCI IF=2.509)
23. Liu J, Zhu L, Wang L, Chen Y, Giri BR, Li J, Cheng G*. Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum. J Vis Exp. 2018 May 22;(135). doi: 10.3791/57514. (2018 SCI IF=1.184)
24. Giri BR, Ye J, Chen Y, Wei C*, Cheng G*. In silico analysis of endogenous siRNAs associated transposable elements and NATs in Schistosoma japonicum reveals their putative roles during reproductive development. Parasitol Res. 2018 May;117(5):1549-1558. (2018 SCI IF=2.558)
25. Giri BR, Du X, Xia T, Chen Y, Li H, Cheng G*. Molecular characterization and expression profile of nanos in Schistosoma japonicum and its influence on the expression several mammalian stem cell factors. Parasitol Res. 2017 Jul;116(7):1947-1954. (2018 SCI IF=2.558)
26. Riaz F, Cheng G*. Exosome-like vesicles of helminths: implication of pathogenesis and vaccine development. Ann Transl Med. 2017 Apr;5(7):175. doi: 10.21037/atm.2017.03.45. (2018 SCI IF=3.689)
27. Zhu L, Zhao J, Wang J, Hu C, Peng J, Luo R, Zhou C, Liu J, Lin J, Jin Y, Davis RE*, Cheng G*. MicroRNAs Are Involved in the Regulation of Ovary Development in the Pathogenic Blood Fluke Schistosoma japonicum. PLoS Pathog. 2016 Feb 12;12(2):e1005423. (2016 SCI IF=7.003)
28. Zhu L, Liu J, Dao J, Lu K, Li H, Gu H, Liu J, Feng X, Cheng G*. Molecular characterization of S. japonicum exosome-like vesicles reveals their regulatory roles in parasite-host interactions. Sci Rep. 2016 May 13;6:25885. (2016 SCI IF=5.228)
29. Cheng G*. Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy. Adv Drug Deliv Rev. 2015 Jan;81:75-93. (2015 SCI IF=15.038)
30. Zhu L, Dao J, Du X, Li H, Lu K, Liu J, Cheng G*. Altered levels of circulating miRNAs are associated Schistosoma japonicum infection in mice. Parasit Vectors. 2015 Apr 1;8:196. (2014 SCI IF=3.234)
31. Zhu L, Liu J, Cheng G*. Role of microRNAs in schistosomes and schistosomiasis. Front Cell Infect Microbiol. 2014 Nov 11;4:165. doi: 10.3389/fcimb.2014.00165. (2014 SCI IF=3.719)
32. Hu, Zhu l, Luo R, Dao J, Zhao J, Shi Y, Li H, Lu K, Feng X, Lin J, Liu J, Cheng G*. Evaluation of protective immune response in mice by vaccination the recombinant adenovirus for expressing Schistosoma japonicum inhibitor apoptosis protein. Parasitol Res. 2014, 113(11):4261-9. (2014 SCI IF=2.327)
33. Dao J, Zhu L, Luo R, Hu C, Wang Y, Li H, Lu K, Liu J, Lin J, Cheng G*. Molecular characterization of SjBIRP, another apoptosis inhibitor, from Schistosoma japonicum. Parasitol Res. 2014, 113(11):4065-71.(2014 SCI IF=2.327)
34. He X, Jing Z*, Cheng G*. MicroRNAs: new regulators of Toll-like receptor signalling pathways. Biomed Res Int. 2014: 945169. doi: 10.1155/2014/945169. (2014 SCI IF=2.706)
35. Cheng G*, Lin J. Parasitic helminths: a useful resource for inflammatory and autoimmune therapy. J Bioanal Biomed. 2013, 5: 075-076.
36. Cheng G*, Luo R, Hu C, Cao J, Jin Y. Deep sequencing-based identification of pathogen-specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum. Parasitology. 2013 Aug 13:1-11. (2013 SCI IF=2.35)
37. Cheng G*, Luo R, Hu C, Lin J, Bai Z, Zhang B, Wang H*. TiO2-based phosphoproteomic analysis of schistosomes: characterization of phosphorylated proteins in the different stages and sex of Schistosoma japonicum. J Proteome Res. 2013 Feb 1;12(2):729-42. (2013 SCI IF=5.001)
38. Luo R, Zhou C, Shi Y, Zhao J, Cheng G*. Molecular characterization of a cytokine-induced apoptosis inhibitor from Schistosoma japonicum. Parasitol Res. 2012 Dec;111(6):2317-24. (2012 SCI IF=2.857)
39. Cheng G* and Jin YX. microRNAs: Potentially Important Regulators for Schistosome Development and Therapeutic Targets against Schistosomiasis. Parasitology. 2012 Apr;139(5):669-79. (2012 SCI IF=2.355)
40. Luo R, Zhou C, Lin J, Yang D, Shi Y, Cheng G*. Identification of in vivo protein phosphorylation sites in human pathogen Schistosoma japonicum by a phosphoproteomic approach. J Proteomics. 2012, 75(3):868-77. (2012 SCI IF=3.888)
41. Chen J, Yang Y, Guo S, Peng J, Liu Z, Li J, Lin J*, Cheng G*. Molecular cloning and expression profiles of Argonaute proteins in Schistosoma japonicum. Parasitol Res. 2010;107(4):889-99. (2010 SCI IF=1.812)
42. Peng J, Yang Y, Feng X, Cheng G*, Lin J*. Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum. Parasitol Res. 2010;106(4):967-76. (2010 SCI IF=1.812)
43. Cheng G#, Fu Z#, Lin J, Shi Y, Zhou Y, Jin Y, Cai Y. In vitro and in vivo evaluation of small interference RNA-mediated gynaecophoral canal protein silencing in Schistosoma japonicum. J Gene Med. 2009;11(5):412-21. (#共同第一作者) (2009 SCI IF=2.986)
44. Cheng G, Zhu L, Mahato RI. Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. Mol Pharm. 2008;5(6):1093-102. (2008 SCI IF=4.024)
45. Cheng G, Davis RE. An improved and secreted luciferase reporter for schistosomes. Mol Biochem Parasitol. 2007;155(2):167-71. (2007 SCI IF=2.896)
46. Cheng G#, Cohen L#, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE. In vivo translation and stability of trans-spliced mRNAs in nematode embryos. Mol Biochem Parasitol. 2007;153(2):95-106. (#co-first author) (2007 SCI IF=2.896)
47. Cheng G, Cohen L, Ndegwa D, Davis RE. The flatworm spliced leader 3'-terminal AUG as a translation initiator methionine. J Biol Chem. 2006 13;281(2):733-43. (2006 SCI IF=5.808)
48. Cheng GF, Lin JJ, Shi Y, Jin YX, Fu ZQ, Jin YM, Zhou YC, Cai YM. Dose-dependent inhibition of gynecophoral canal protein gene expression in vitro in the schistosome (Schistosoma japonicum) by RNA interference. Acta Biochim Biophys Sin. 2005;37(6):386-90. (2005 SCI IF=0.505)
49. Cheng GF, Lin JJ, Feng XG, Fu ZQ, Jin YM, Yuan CX, Zhou YC, Cai YM. Proteomic analysis of differentially expressed proteins between the male and female worm of Schistosoma japonicum after pairing. Proteomics. 2005;5(2):511-21. (2005 SCI IF=6.08)
BOOK CHAPTERS(*Corresponding author)
1. Zhu L, Cheng G* (2018) miRNA therapeutics to target multiple molecular pathways: current status, challenges and future prospects. In: Ram I. Mahato, Deepak Chitkara and Anupama Mittal (eds) Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology. CRC Press/Taylor & Francis.pp381-418.
2. Cheng G, Danquah M and Mahato RI (2009) MicroRNAs as therapeutic targets for cancer. In: Lu Y and Mahato RI (eds) Pharmaceutical Perspectives of Cancer Therapeutics (ISBN: 978-1-4419-0130-9). Springer, New York,NY. pp441-474.