炎症免疫信号转导与其相关性疾病研究组

Laboratory of Inflammatory Signal Transduction and Related Diseases

近年发表论文

1. Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis induces transition of macrophages into epithelioid macrophages by downregulating iNOS / NO-mediated H3K27 trimethylation in macrophages. Molecular Immunology  117:189–200, 2020.  doi.org/10.1016/j.molimm.2019.11.013

2.Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis promotes caspase-9/caspase-3-mediated apoptosis in macrophages. Molecular and Cellular Biochemistry  457:179–189, 2019. DOI 10.1007/s11010-019-03522-x 

3.Vascular endothelial cells senescence is associated with NLRP3 inflammasome activation via ROS/TXNIP pathway. The International Journal of Biochemistry & Cell Biology. 84: 22-34, 2017. doi: 10.1016/j.biocel.2017.01.001.

4.Downregulation of B-myb promotes senescence via ROS mediated p53/p21 pathway in vascular endothelial cells. Cell Proliferation  A(50)2, 2017. doi: 10.1111/ cpr.12319. Epub 2016 Nov 23  

5.SOCS3 and its role in associated diseases. Human Immunology  76(10):775-780, 2015. doi: 10.1016/ j.humimm. 2015.09.037.

6.  OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation. Inflammation Research  63(1):33-43, 2014. doi: 10.1007/s00011-013-0667-3.

7.The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by mycobacterium tuberculosis ESAT-6. Inflammation  37(3):880-892, 2014. doi: 10.1007/s10753-013-9808-7.

8.Modification of SR-PSOX functions by multi-point mutations of basic amino acid residues. Biochimie  95(1):224-230, 2013. doi: 10.1016/j.biochi.2012.09.016.

9.  The essential role of p38 MAPK in mediating the interplay of oxLDL and IL-10 inregulating endothelial cell apoptosis. European Journal of Cell Biology  92(4-5):150-159, 2013. doi: 10.1016/j.ejcb.2013.01.001.

10.The association of elevated 2′,5′-oligoadenylate -dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization. Lung Cancer 78:30-38, 2012. doi: 10.1016/j.lungcan.2012.07.010.

11.An essential function for MKP5 inthe formation of oxidized low density lipid-induced foam cells. Cellular Signalling  24:1889-1898, 2012. doi: 10.1016/j.cellsig.2012.05.017

12.Function modification of SR-PSOX by point mutations of basic amino acids. Lipids in health and disease  10:59, 2011. doi:10.1186/ 1476-511X-10-59

13.Interleukin-10 down-regulates oxLDL induced expression of scavenger receptor A and Bak-1 inmacrophages derived from THP-1 cells. Archives of Biochemistry and Biophysics  512:30-37, 2011. doi: 10.1016/j.abb.2011.05.017.

14. Effect of overexpression of human SR-A1 on ox-LDL uptake and apoptosis in 293T cells. International Immunopharmacology   11(11):1752-1757, 2011. doi: 10.1016/j.intimp.2011.07.001.

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