分子神经科学课题组

Molecular Neuroscience Lab

彭长庚 博士

同济大学青年百人,特聘研究员 

课题组组长,博士生导师

生理学会转化神经科学分会委员

changgeng.peng@tongji.edu.cn

教育经历

2008.2- 2012.5  博士,德国国家环境与健康研究中心/慕尼黑工业大学,生物学。

2003.9-2006.6   硕士,中科院上海生命科学研究院健康科学研究所,分子生物与生物化学专业。

1999.9-2003.6   学士,山西大学,生物技术专业。

工作经历

2017.9-至今     特聘研究员、硕士研究生导师、博士研究生导师,同济大学医学院、转化医学高等研究院。

2012.6-2017.6   博士后研究员,瑞典卡罗林斯卡医学院医学生化与生物物理系。  

2006.7-2007.9   研究助理,中科院上海生命科学研究院健康科学研究所。

研究方向


miRNA敲除小鼠模型研究多基因参与的复杂慢性疾病的机制和药物,包括三个方面:

 

1) 感觉神经元发育和相关疾病(疼痛、听力损伤)的机制及药物研究。

 

2) 研究中脑多巴胺神经元(mDA)的存活机制,探寻帕金森病的早期诊断biomarker和诊断方法。

 

3) 神经和免疫。


论文


1. Zhao R, Yang J, Zhai Y, Zhang H, Zhou Y, Hong L, Yuan D, Xia R, Liu Y, Pan J, Shafi S, Shi G, Zhang R, Luo D, Yuan J, Pan D, Peng C*, Li S*, Sun M*. Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity. Nat Immunol. 2024 Aug 5. doi: 10.1038/s41590-024-01921-x. (*通讯作者)

2. Zhu F, Yang T, Ning M, Liu Y, Xia W, Fu Y, Wen T, Zheng M, Xia R, Qian R, Li Y, Sun M, Liu J, Tian L*, Zhou Q*, Yu X*, Peng C*. MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks. Front Immunol. 2024 May 10;15:1366319. doi: 10.3389/fimmu.2024.1366319. PMID: 38799464; PMCID: PMC11116640. (*通讯作者)

3. Yan Fu, Liting Sun, Fengting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu*, Changgeng Peng*. Ectopic expression of Nav1.7 in spinal dorsal horn neurons induced by NGF contributed to neuropathic pain in a mouse spinal cord injury model. Front. Mol. Neurosci., 03 March 2023. Volume 16 - 2023

4. Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Ruilong Xia, Ting Wen, Wei Xia, Ran Qian, Fengting Zhu, Yuanying Liu, Zhicheng Tian, Lamei Li, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou-Gang Xie, Changgeng Peng. Nav1.7 and Nav1.8 form supramolecular active clusters with TRKB in mouse and human DRG neurons during development of neuropathic pain. medRxiv 2022.11.05.22281929; doi: https://doi.org/10.1101/2022.11.05.22281929

5. Liting Sun, Changgeng Peng, Elbert Joosten, Chi Wai Cheung, Fei Tan, Wencheng Jiang, and Xiafeng Shen. Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application. Neural Plast. 2021; 2021: 5607898.

6. Yong-Hui Zhang, Hao-Yu Hu, Yuan-Chang Xiong, Changgeng Peng, Li Hu, Ya-Zhuo Kong, Yu-Ling Wang, Jia-Bao Guo, Sheng Bi, Tie-Shan Li, Li-Juan Ao, Chu-Huai Wang, Yu-Long Bai, Lei Fang, Chao Ma, Lin-Rong Liao, Hao Liu, Yi Zhu, Zhi-Jie Zhang, Chun-Long Liu, Guo-En Fang, Xue-Qiang Wang. Exercise for Neuropathic Pain: A Systematic Review and Expert Consensus. Front Med (Lausanne). 2021 Nov 24;8:756940.

7. Sun L, Xia R, Jiang J, Wen T, Huang Z, Qian R, Zhang M, Zhou M, Peng C. MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord. Progress in Neurobiology, 2021 Jul;202:102024.

8. Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl AM, Gecz J, Han D, Liu D, Xu K, Hu H. In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy. Brain. 2021 Jun 2: doi: 10.1093/brain/awab209.

9. Zhou P, Qi Y, Fang X, Yang M, Zheng S, Liao C, Qin F, Liu L, Li H, Li Y, Ravindran E, Sun C, Wei X, Wang W, Fang L, Han D, Peng C, Chen W, Li N, Kaindl AM, Hu H. Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1. iScience. 2021 May 24;24(6):102645.

10. Nouri P, Goetz S, Rauser B, Irmler M, Peng C, Trumbach D, Kempny C, Lechermeier C, Brybiok A, Dulugos A, Euchner E, Beckers J, Brodski C, Klumper C, Wurst W, Prakash N. Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling. Frontiers in Cell and Developmental Biology. 2020 Oct 26;8:587778.

11. Sun L#, Liu Y# and Peng C. Different Manners of Interplay between MicroRNAs and Gene Programs in Neuronal Specification. Journal of Cell Signaling. 2018, 3:4. DOI: 10.4172/2576-1471.1000193.

12. Peng C§,Furlan A, Zhang M, Su J, Lübke M, Lönnerberg P, Abdo H, Sontheimer J, Sundström E, Ernfors P. Termination of cell-type specification gene programs by miR-183 cluster determines the population sizes of low threshold mechanosensitive neurons. Development. 2018 Sep 25;145(18):dev165613. (§通讯作者).

13. Zhang M, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, O, Watanabe M, M, Mitsios N, Mulder J, Harkany T*,Hökfelt T*. Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity. Journal Of Clinical Investigation. 2018 July 30. https://doi.org/10.1172/JCI120913.

14. Yang S, Toledo E, Rosmaninho P, Peng C, Uhlén P, Castro D, Arenas E. A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Communications Biology volume 1, Article number: 75 (2018).

15. Peng C, Li L, Zhang M, Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J and Ernfors P. MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science. 2017 Jun 16;356(6343):1168-1171. (Science同期杂志上发表了Perspective review, F1000优秀论文)

16. Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N. A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. J Neurosci. 2012 Sep 19;32(38):13292-308. (F1000优秀论文)

17. Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, and Le W. Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. J Neurosci. 2011 Sep;31, 12802-12815.

18. Peng C, Fan S, Li X, Fan X, Ming M, Sun Z, Le W. Overexpression of pitx3 upregulates expression of BDNF and GDNF in SH-SY5Y cells and primary ventral mesencephalic cultures. FEBS Lett. 2007 Apr 3;581(7):1357-61. Epub 2007 Mar 2.

19. Li X, Peng C, Li L, Ming M, Yang D, Le W. Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation. J Gerontol A Biol Sci Med Sci. 2007 Sep;62(9):943-50.

20. Yang, D., Peng, C., Li, X., Fan, X., Li, L., Ming, M., Chen, S., and Le, W. Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures. J Neurosci Res.2008 Nov; 86(15), 3393-3400.

21. Li X, Yang D, Li L, Peng C, Chen S, Le W. Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures. Neurochem Int. 2007 Jun;50(7-8):959-65. Epub 2007 May 3.


获奖情况

1. 《镇痛止痒1.1类小分子药物研发》,2023年中国发明协会银奖,证书号:3102117。第一完成人。

2. 同济大学2021年十大最具转化潜力科技成果奖.

3. 《中脑多巴胺系统发育及神经元变性在帕金森病中的基因调控和分子机制》2008年中华医学科技奖二等奖,证书号:200802106P1009。


专利


1. ANALGESIC AND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR.2021329457, 发明人设计人:彭长庚,孙立婷,夏瑞龙。已授权, 澳大利亚。

2. ANALGESIC AND ANTIPRURITIC PHARMACEUTICAL COMPOSITION AND APPLICATION METHOD THEREFOR. 18/171,431, 发明人设计人:彭长庚,孙立婷,夏瑞龙。已授权, 美国。

3. 《一种止痛止痒药物组合物及其应用方法》,专利号:ZL202010845095.2,发明人设计人:彭长庚,孙立婷,夏瑞龙。

4. 《一种制备TrkB-Tomato小鼠的方法及其应用》专利申请号:202210052495.7,发明人设计人:彭长庚,解柔刚,孙立婷,夏瑞龙。

5.《Pitx3基因及其启动子的应用》,专利号:ZL200610025416.4,发明人设计人:乐卫东,彭长庚

联系我们
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Changgeng.peng@tongji.edu.cn

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